TRPM8

TRPM8 (also known as TRPP8) is a calcium ion channel that is triggered by cold temperatures, menthol, and other small molecule agonists. TRPM8 belongs to the melastatin subfamily of TRP proteins. Calcium ions mediate key cellular functions, and activation of TRPM8 channels which can induce programmed cell death (apoptosis) in TRPM8-expressing cells.

In normal human tissues, TRPM8 is highly expressed in the prostate, a gland in the male reproductive system. TRPM8 expression is maintained in prostate hyperplasia and prostate cancer. There is evidence that TRPM8 is also expressed in other tumor types. Dendreon has synthesized small molecule agonists, including D-3263 HCI, which activate the TRPM8 ion channel and can induce cell death (apoptosis). The lead investigational molecule, D-3263 HCI, is in a Phase 1 PHASE 1 CLINICAL TRIALThe first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, Phase 1 trials usually include only a small number of patients.Close trial for clinical evaluation in patients with solid tumors.